LOS ANGELES — Staggered after one of the most destructive natural disasters in Southern California history, thousands of heartbroken families, burned-out business owners and beleaguered leaders across Los Angeles County are beginning to ponder another monumental task: rebuilding what was lost and charting a path forward.

Alex Rosewood and nearly her entire family in Altadena, northeast of Los Angeles, lost their homes — her father, whom she and her husband were living with, and her aunt, uncle and cousin next door.

Lost were the keepsakes of a lifetime of family relationships: Rosewood’s grandmother’s playing cards and unfinished quilt. Her wedding photos. Heirlooms from her grandfather, who served in the Navy. All things she wished she could have saved in their frantic flight as smoke turned the sky gray and her cousin’s house began to catch fire.

But Altadena remains home.

“We all plan to rebuild, for sure,” she said.

The traumatized region made it through Wednesday without another major fire breaking out, after forecasters had warned of another round of particularly dangerous winds.

Yet even with flames still leaping in two of the largest fires, which have killed 25 and destroyed more than 12,000 structures, government officials talked Wednesday of the epic job that will unspool over years: clearing Altadena, Pacific Palisades and other ravaged communities of toxic ash and debris, then rebuilding homes, restaurants, schools, boutiques, banks and houses of worship — all while finding financing for it all.

Because of the ongoing firefighting battle and the likelihood of dangerous refuse in burned areas, many anxious residents have yet to return to see what, if anything, is left of their homes. The losses range from multimillion-dollar ocean-view mansions to modest homes that once welcomed returning World War II GIs.

While talking of rebuilding can be a comfort for those eager for a return to normalcy, much remains unknown.

What will the new neighborhoods look like? Will fire-resistant materials and designs be used? Are more and wider roads needed to allow swifter evacuations and easier access for fire engines during future infernos?

In the coveted seaside hills, there always is the impulse to rebuild after fires — it’s happened many times. But there are inevitable questions about whether it’s sensible to keep rebuilding in known high-risk areas, especially in an age of climate change.

“It’s going to be a while before we can get in there and build anything,” Michael Hricak, an adjunct professor of architecture at the University of Southern California, said in referring to the dangerous chemicals and rubble left behind.

As for new construction, “it’s not being tougher than Mother Nature. It’s being somewhat respectful of Mother Nature and knowing what the challenges are.”

“Are we just inviting another problem down the road?” Hricak said.

The fires struck at a challenging time, with the city in the midst of a post-pandemic transition that has reordered work life and left many downtown buildings with high vacancy rates.