The COVID-19 vaccines are on track for a big recipe change this fall.

Today’s vaccines still contain the original coronavirus strain, the one that started the pandemic - even though that was long ago supplanted by mutated versions as the virus rapidly evolves.

This month, the Food and Drug Administration’s scientific advisers said the next round of shots in the U.S. should only include protection against the newest variants that are now dominant worldwide - a branch of the omicron family tree named XBB.

The FDA will make the final decision. Vaccine makers said during the meeting that they could have updated vaccines available within months, depending on the strain.

While infections have declined, the virus could be a real concern next winter, FDA’s vaccine chief Dr. Peter Marks said as the daylong meeting began.

“We’re concerned that we may have another wave of COVID-19 during a time when the virus has further evolved, immunity of the population has waned further, and we move indoors for wintertime,” he said.

The FDA had told Americans to expect an updated fall vaccine against COVID-19, just like they get a new flu shot every fall. Even though most of the population has either been infected or had at least one round of vaccinations, the coronavirus keeps churning out new varieties.

What’s in use in the U.S. now are combination shots from Pfizer and Moderna that mix the original strain with protection against last year’s most common omicron variants, called BA. 4 and BA.5. But just 17% of Americans rolled up their sleeves for a combo booster.

And while the FDA did allow seniors and others at high risk to get an extra booster dose this spring, most people will be many months beyond their last shot by fall.

Those currently available shots do still help prevent severe disease and death even as XBB variants have taken over. But protection gradually wanes over time and was short-lived against milder infection even before the virus, inevitably, evolved again.

“We need a better vaccine. We should be updating it,” said one adviser, Dr. Eric Rubin, an infectious disease doctor at Brigham and Women’s Hospital in Boston.

Last year when regulators were struggling to decide how to update the vaccine, a combo shot seemed like the safest bet. Omicron was pretty new, and there was no way to know how long it would stick around or if the next big coronavirus change would more resemble the original strain.

Keeping the original strain in the shot actually has a downside called “imprinting.” After repeated exposure to the original strain, people’s immune systems tended to recognize and respond more strongly to it than to the half of the new booster dose that was brand new.

The FDA advisory panel agreed that the fall shot should just target XBB variants.

Another challenge: Deciding which XBB variant to target - since what’s spreading now likely will have mutated again by winter.

Regulators will be making their best guess, just like they do every year in setting the recipe for the fall flu vaccine.

The FDA has identified three XBB subtypes as the top strain choices.