The U.S. Coast Guard says a missing submersible imploded near the wreckage of the Titanic, killing all five people on board.

Coast Guard officials said during a news conference Thursday that they’ve notified the families of the crew of the Titan, which has been missing for several days. Debris found during the search for the vessel “is consistent with a catastrophic implosion of the vessel,” said Rear Adm. John Mauger of the First Coast Guard District.

“The outpouring of support in this highly complex search operation has been great appreciated. Our most heartfelt condolences go out to the friends and loved ones of the crew,” Mauger said.

OceanGate Expeditions said in a statement that all five people on board, including company CEO Stockton Rush, are believed to be dead. Rush, Shahzada Dawood and his son Suleman Dawood, Hamish Harding, and Paul-Henri Nargeolet “have sadly been lost,” OceanGate said in a statement.

OceanGate did not provide details when the company announced the “loss of life” in a statement or how officials knew the crew members perished. The Titan’s 96-hour oxygen supply likely ended early Thursday.

OceanGate has been chronicling the Titanic’s decay and the underwater ecosystem around it via yearly voyages since 2021.

The Titan was estimated to have about a four-day supply of breathable air when it launched Sunday morning in the North Atlantic - but experts have emphasized that was an imprecise approximation to begin with and could be extended if passengers have taken measures to conserve breathable air. And it’s not known if they survived since the sub’s disappearance.

Rescuers have rushed ships, planes and other equipment to the site of the disappearance. On Thursday, the U.S. Coast Guard said an undersea robot sent by a Canadian ship had reached the sea floor, while a French research institute said a deep-diving robot with cameras, lights and arms also joined the operation.

Authorities have been hoping underwater sounds might help narrow their search, whose coverage area has been expanded to thousands of miles - twice the size of Connecticut and in waters 2 1/2 miles (4 kilometers) deep. Coast Guard officials said underwater noises were detected in the search area Tuesday and Wednesday.

Jamie Pringle, an expert in Forensic Geosciences at Keele University, in England, said even if the noises came from the submersible, “The lack of oxygen is key now; even if they find it, they still need to get to the surface and unbolt it.”

The Titan was reported overdue Sunday afternoon about 435 miles (700 kilometers) south of St. John’s, Newfoundland, as it was on its way to where the iconic ocean liner sank more than a century ago. OceanGate Expeditions, which is leading the trip, has been chronicling the Titanic’s decay and the underwater ecosystem around it via yearly voyages since 2021.

By Thursday morning, hope was running out that anyone on board the vessel would be found alive.

Dr. Rob Larter, a marine geophysicist with the British Antarctic Survey, emphasized the difficulty of finding something the size of the submersible, which is about 22 feet (6.5 meters) long and 9 feet (nearly 3 meters) high.

“You’re talking about totally dark environments,” in which an object several dozen feet away can be missed, he said. “It’s just a needle in a haystack situation unless you’ve got a pretty precise location.”

Newly uncovered allegations suggest there had been significant warnings made about vessel safety during the submersible’s development.

Broadcasters around the world started newscasts at the critical hour Thursday with news of the submersible. The Saudi-owned satellite channel Al Arabiya showed a clock on air counting down to their estimate of when the air could potentially run out.

Captain Jamie Frederick of the First Coast Guard District said a day earlier that authorities were still holding out hope of saving the five passengers onboard.

“This is a search-and-rescue mission, 100%,” he said Wednesday.

Retired Navy Capt. Carl Hartsfield, now the director of the Woods Hole Oceanographic Systems Laboratory, said the sounds detected have been described as “banging noises,” but he warned that search crews “have to put the whole picture together in context and they have to eliminate potential manmade sources other than the Titan.” Frederick acknowledged Wednesday that authorities didn’t what the sounds were.

The report of sounds was encouraging to some experts because submarine crews unable to communicate with the surface are taught to bang on their submersible’s hull to be detected by sonar.

The U.S. Navy said in a statement Wednesday that it was sending a specialized salvage system that’s capable of hoisting “large, bulky and heavy undersea objects such as aircraft or small vessels.”

The Titan weighs 20,000 pounds (9,000 kilograms). The U.S. Navy’s Flyaway Deep Ocean Salvage System is designed to lift up to 60,000 pounds (27,200 kilograms), the Navy said on its website.

Lost aboard the vessel is pilot Stockton Rush, the CEO of OceanGate. His passengers are: British adventurer Hamish Harding; Pakistani businessman Shahzada Dawood and his son Suleman; and French explorer and Titanic expert Paul-Henry Nargeolet.

In the first comments from Pakistan since the Titan vanished, Pakistani Foreign Ministry spokesperson Mumtaz Zahra Baloch said Thursday that officials have confidence in the search efforts.

“We would not like to speculate on the circumstances of this incident and we would also like to respect the wishes of the Dawood family that their privacy be respected,” she said.

At least 46 people successfully traveled on OceanGate’s submersible to the Titanic wreck site in 2021 and 2022, according to letters the company filed with a U.S. District Court in Norfolk, Virginia, that oversees matters involving the Titanic shipwreck.

One of the company’s first customers characterized a dive he made to the site two years ago as a “kamikaze operation.”

“Imagine a metal tube a few meters long with a sheet of metal for a floor. You can’t stand. You can’t kneel. Everyone is sitting close to or on top of each other,” said Arthur Loibl, a retired businessman and adventurer from Germany. “You can’t be claustrophobic.”

During the 2 1/2-hour descent and ascent, the lights were turned off to conserve energy, he said, with the only illumination coming from a fluorescent glow stick.

The dive was repeatedly delayed to fix a problem with the battery and the balancing weights. In total, the voyage took 10 1/2 hours.

The submersible had seven backup systems to return to the surface, including sandbags and lead pipes that drop off and an inflatable balloon.

Nick Rotker, who leads underwater research for the nonprofit research and development company MITRE, said the difficulty in searching for the Titan has underscored the U.S.’s need for more underwater robots and remotely operated underwater vehicles.

“The issue is, we don’t have a lot of capability or systems that can go to the depth this vessel was going to,” Rotker said.

Nicolai Roterman, a deep-sea ecologist and lecturer in marine biology at the University of Portsmouth, England, said the disappearance of the Titan highlights the dangers and unknowns of deep-sea tourism.

“Even the most reliable technology can fail, and therefore accidents will happen. With the growth in deep-sea tourism, we must expect more incidents like this.”

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Associated Press writers Jon Gambrell in Dubai, United Arab Emirates; Ben Finley in Norfolk, Virginia; Frank Jordans in Berlin; Danica Kirka in London; and John Leicester in Paris contributed to this report.